HCID 12043677, compound → HCID 22456195, compound

HRID 2186419Notes

Reaction equation

HRID 2186419 reaction equation
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=O)[CH2:7][C:8]([CH3:13])([CH3:12])[O:9]2)=[CH:4][CH:3]=1.[CH2:15]([Mg]Cl)[CH2:16][CH2:17][CH3:18].BrC1C=C2C(C(C(C)C)=CC(C)(C)O2)=CC=1>>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([CH2:15][CH2:16][CH2:17][CH3:18])=[CH:7][C:8]([CH3:13])([CH3:12])[O:9]2)=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 12043677HCID 12043677, compoundHCID 14755365HCID 14755365, compound2×HCID 178418265HCID 178418265, compound

Product 1

HCID 22456195HCID 22456195, compound

Procedure

7-bromo-2,2-dimethyl-chroman-4-one (Compound 65, 1.58 g, 6.20 mmol) was treated by the procedure described above (using n-butyl magnesium chloride) for the preparation of Compound 66 to produce the title compound as a clear oil: (1.07 g, 59%).

Sources & evidence

ORD record
ord-ff11d37dd5174455b690d99114c0a49c
Source dataset
uspto-grants-2002_06
Patent number
US06403638B1

Reaction notes

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