HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → HCID 70193430, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | tert-Butyl carbazate | HCID 70091 | — |
| Reactant | β-Methyl-4-(3-pyridinyl)-1H-imidazole-1-propanal | HCID 18759767 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 70193430 | HCID 70193430 | — |
Reaction Steps
(R/S)-3-(4-pyridin-3-yl-imidazol-1-yl)-butan-1-al (11) (1 mmol) is dissolved in 10 mL HOAc and t-butyl hydrazinecarboxylate (1.1 mmol) is added. After 1 h, NaHB(OAc)3 (5 mmol) is added at 25° C. After 2 h, the reaction is poured into sodium carbonate in water and EtOAc. The water layer is removed, the organics are washed with brine, and dried over sodium sulfate. The solvent is removed in vacuo to leave the product (32).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06403776B1 |
| Source dataset | uspto-grants-2002_06 |
| ORD ID | ord-ecf2ad3b1cd74d89a09ecf67779636c5 |
| Source note | uspto-grants-2002_06 |