反应详情

N-Bromosuccinimide (2.4 g) was added to a solution of 4-methoxy-2-methylsulfanylbenzooxazole (2.63 g) in acetonitrile (80 ml) and the mixture stirred for 18 hours. It was then partitioned between dichloromethane (200 ml) and water (200 ml). The organics were washed with water (200 ml), dried over magnesium sulphate, filtered and the solvent removed in vacuo. Purification by column chromatography on silica eluting with 10% ethyl acetate in heptane afforded the title compound as a white solid (1.25 g).

1. customIt was then partitioned between dichloromethane (200 ml) and water (200 ml)
2. washThe organics were washed with water (200 ml)
3. dry with materialdried over magnesium sulphate
4. filtrationfiltered
5. customthe solvent removed in vacuo
6. customPurification by column chromatography on silica eluting with 10% ethyl acetate in heptane