HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Difluoromethoxy-2-ethylbenzooxazole-7-carboxylic acid → 4-Difluoromethoxy-2-ethylbenzooxazole-7-carboxylic acid (2-ethyl-4-methyl-2H-pyrazol-3-yl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Difluoromethoxy-2-ethylbenzooxazole-7-carboxylic acid | HCID 22456643 | — |
| Reactant | 1-Ethyl-4-methyl-1H-pyrazol-5-amine | HCID 22456658 | — |
| Product | 4-Difluoromethoxy-2-ethylbenzooxazole-7-carboxylic acid (2-ethyl-4-methyl-2H-pyrazol-3-yl)-amide | HCID 10270122 | 40% |
Reaction Steps
Starting from 4-difluoromethoxy-2-ethylbenzooxazole-7-carboxylic acid (150 mg) and 2-ethyl-4-methyl-2H-pyrazol-3-ylamine (90 mg). Purification by column chromatography on silica eluting 2:1 ethyl acetate-heptane followed by ethyl acetate afforded the title compound as a white solid (85 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06403791B1 |
| Source dataset | uspto-grants-2002_06 |
| ORD ID | ord-21921eee26c14d179d3557a468f415d1 |
| Source note | uspto-grants-2002_06 |