4-Amino-3,5-dimethylisoxazole → HCID 9858040, compound

HRID 2186459Notes

Reaction equation

HRID 2186459 reaction equation
[CH3:1][O:2][C:3]1[C:8]2[N:9]=[C:10]([CH2:12][CH3:13])[O:11][C:7]=2[C:6]([C:14]([OH:16])=O)=[CH:5][CH:4]=1.[CH3:17][C:18]1[C:22]([NH2:23])=[C:21]([CH3:24])[O:20][N:19]=1>>[CH3:17][C:18]1[C:22]([NH:23][C:14]([C:6]2[C:7]3[O:11][C:10]([CH2:12][CH3:13])=[N:9][C:8]=3[C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)=[O:16])=[C:21]([CH3:24])[O:20][N:19]=1

Participants

3

Reactant 2

HCID 1820404-Amino-3,5-dimethylisoxazoleHCID 18316647HCID 18316647, compound

Product 1

HCID 9858040HCID 9858040, compoundYield 64%

Procedure

Starting from 4-methoxy-2-ethylbenzooxazole-7-carboxylic acid (0.23 g) and 3,5-dimethylisoxazol-4-ylamine (0.1 g). Purification by column chromatography on silica eluting with ethyl acetate afforded the title compound as a cream solid (0.18 g).

Workup

  1. customPurification by column chromatography on silica eluting with ethyl acetate

Sources & evidence

ORD record
ord-be0a0a4b58f849e28562b09335afec18
Source dataset
uspto-grants-2002_06
Patent number
US06403791B1

Reaction notes

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