HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → 4-Difluoromethoxy-2-ethylbenzooxazole-7-carboxylic acid (2-methyl-2H-pyrazol-3-yl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | 2-Methyl-2H-pyrazol-3-ylamine | HCID 136927 | — |
| Reactant | 4-Difluoromethoxy-2-ethylbenzooxazole-7-carboxylic acid 4-nitrophenyl ester | HCID 54536097 | — |
| Solvent | Hexane | HCID 8058 | — |
| Product | 4-Difluoromethoxy-2-ethylbenzooxazole-7-carboxylic acid (2-methyl-2H-pyrazol-3-yl)-amide | HCID 10131827 | 15.7% |
Reaction Steps
Starting from 4-difluoromethoxy-2-ethylbenzooxazole-7-carboxylic acid 4-nitro-phenyl ester (100 mg) and 2-methyl-2H-pyrazole-3-ylamine (51 mg). Purification by column chromatography on silica eluting with ethyl acetate afforded, after trituration with a mixture of diethyl ether and hexane, the title compound as a pale yellow solid (14mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06403791B1 |
| Source dataset | uspto-grants-2002_06 |
| ORD ID | ord-bcdf2e6c90b44afc930c59b0e6c63fbc |
| Source note | uspto-grants-2002_06 |