5-Amino-1-methyl-1H-pyrazole-4-carbonitrile → HCID 10112717, compound

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Reaction Steps

Starting from 4-difluoromethoxy-2-(morpholin-4-yl)-benzooxazole-7-carboxylic acid 4-nitrophenyl ester (100 mg) and 5-amino-1-methyl-1H-pyrazole-4-carbonitrile (56 mg). Purification by column chromatography on silica eluting with 5% methanol in dichloromethane followed by preparative thin layer chromatography eluting with 3% methanol in dichloromethane afforded the title compound as a white solid (28 mg).

Provenance & Evidence