5-Amino-1-methyl-1H-pyrazole-4-carbonitrile → HCID 10156722, compound

Participants

Reaction Steps

Starting from 4-methoxy-2-(morpholin-4-yl)-benzooxazole-7-carboxylic acid 4-nitro-phenyl ester (200 mg) and 5-amino-1-methyl-1H-pyrazole-4-carbonitrile (122 mg). Purification by column chromatography on silica eluting with 80% ethyl acetate in heptane followed by 1% methanol in dichloromethane afforded, after trituration with diethyl ether, the title compound as a white solid (132 mg).

Provenance & Evidence