HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Amino-1-methyl-1H-pyrazole-4-carbonitrile → 4-Difluoromethoxy-2-(piperidin-1-yl)-benzooxazole-7-carboxylic acid (4-cyano-2-methyl-2H-pyrazol-3-yl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Amino-1-methyl-1H-pyrazole-4-carbonitrile | HCID 219740 | — |
| Reactant | 4-Difluoromethoxy-2-(piperidin-1-yl)-benzooxazole-7-carboxylic acid 4-nitro-phenyl ester | HCID 69838534 | — |
| Product | 4-Difluoromethoxy-2-(piperidin-1-yl)-benzooxazole-7-carboxylic acid (4-cyano-2-methyl-2H-pyrazol-3-yl)-amide | HCID 10201983 | 14.9% |
Reaction Steps
Starting from 4-difluoromethoxy-2-(piperidin-1-yl)-benzooxazole-7-carboxylic acid 4-nitro-phenyl ester (0.35 g) and 5-amino-1-methyl-1H-pyrazole-4-carbonitrile (0.197 g). Purification by column chromatography on silica eluting with 50% ethyl acetate in heptane afforded the title compound as a white solid (50 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06403791B1 |
| Source dataset | uspto-grants-2002_06 |
| ORD ID | ord-c96463d8c8374bc2adb91e3d0af30960 |
| Source note | uspto-grants-2002_06 |