HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Ethyl-1-methyl-1H-pyrazol-5-amine → 4-Difluoromethoxy-2-ethylbenzooxazole-7-carboxylic acid (4-ethyl-2-methyl-2H-pyrazol-3-yl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Ethyl-1-methyl-1H-pyrazol-5-amine | HCID 22456644 | — |
| Reactant | 4-Difluoromethoxy-2-ethylbenzooxazole-7-carboxylic acid 4-nitrophenyl ester | HCID 54536097 | — |
| Product | 4-Difluoromethoxy-2-ethylbenzooxazole-7-carboxylic acid (4-ethyl-2-methyl-2H-pyrazol-3-yl)-amide | HCID 9947183 | — |
Reaction Steps
Starting from 4-difluoromethoxy-2-ethylbenzooxazole-7-carboxylic acid 4-nitro-phenyl ester (100 mg) and 4-ethyl-2-methyl-2H-pyrazol-3-ylamine (64 mg). Purification by column chromatography on silica eluting with 5% methanol in dichloromethane afforded the title compound as an off white solid (55 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06403791B1 |
| Source dataset | uspto-grants-2002_06 |
| ORD ID | ord-8ccb8b1a631248d6bfc7e43dd395bb52 |
| Source note | uspto-grants-2002_06 |