HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Difluoromethoxy-2-ethylbenzooxazole-7-carboxylic acid → 4-Difluoromethoxy-2-ethylbenzooxazole-7-carboxylic acid (5-methyl-3-trifluoromethylisoxazol-4-yl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Difluoromethoxy-2-ethylbenzooxazole-7-carboxylic acid | HCID 22456643 | — |
| Reactant | 5-Methyl-3-(trifluoromethyl)isoxazol-4-amine | HCID 22456648 | — |
| Product | 4-Difluoromethoxy-2-ethylbenzooxazole-7-carboxylic acid (5-methyl-3-trifluoromethylisoxazol-4-yl)-amide | HCID 10111887 | 10.2% |
Reaction Steps
Starting from 4-difluoromethoxy-2-ethylbenzooxazole-7-carboxylic acid (0.1 g) and 5-methyl-3-trifluoromethylisoxazol-4-ylamine (78 mg). Purification by column chromatography eluting with 20-30% ethyl acetate in hexane afforded the title compound as a white solid (16 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06403791B1 |
| Source dataset | uspto-grants-2002_06 |
| ORD ID | ord-1a490aa917c44ad684b2696f20f68fe3 |
| Source note | uspto-grants-2002_06 |