HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → HCID 11789356, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Methyl 4-methoxyacetoacetate | HCID 123500 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 11789356 | HCID 11789356 | 99.8% |
Reaction Steps
In a 10 liter autoclave were put 1473 g (10.08 mol) of methyl 4-methoxy-3-oxobutyrate, 2210 ml of ethanol, and 4.59 g (5.09 mmol) of Ru2Cl4((S)-Tol-BINAP)2.NEt3, and asymmetric hydrogenation was carried out at 100° C. under a hydrogen pressure of 4000 kPa for 4 hours (conversion: 100%). The solvent was removed by evaporation to yield 1490 g of the title compound as liquid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06403804B1 |
| Source dataset | uspto-grants-2002_06 |
| ORD ID | ord-648caafdaf65481893203e627008edb3 |
| Source note | uspto-grants-2002_06 |