Ethanol → HCID 11822048, compound

Participants

Reaction Steps

In a 200 ml autoclave were charged 40 g (0.13 mol) of ethyl 4-benzyloxycarbonylamino-3-oxobutyrate, 120 ml of ethanol, and 173 mg (0.102 mmol) of Ru2Cl4((R)-Tol-BINAP)2.NEt3, and asymmetric hydrogenation was carried out at 50° C. under a hydrogen pressure of 30 torr. for 17 hours (conversion: 98.4%; optical purity: 94%e.e.). Ethanol was evaporated under reduced pressure to furnish 38.9 g of the title compound as liquid. An aliquot of the product was purified to find that the yield was 91%.

Provenance & Evidence