Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | 4-Chloro-3-hydroxybutyric acid ethyl ester, (3R)- | HCID 2734445 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 11789689 | HCID 11789689 | 79.4% |
Reaction Steps
In a 200 ml four-necked flask were charged 20.0 g (0.12 mol) of ethyl (R)-4-chloro-3-hydroxybutyrate, 15.6 g (0.24 mol) of sodium azide and 80 ml of DMF, and the reaction mixture was stirred for 24 hours at a reaction temperature of about 100° C. After cooling the reaction mixture, the reaction mixture was diluted with 100 ml of toluene, washed with 50 ml of water, and concentrated to give 16.5 g (79%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06403804B1 |
|---|
| Source dataset | uspto-grants-2002_06 |
|---|
| ORD ID | ord-7bef6720545a43558abd45b39df2490e |
|---|
| Source note | uspto-grants-2002_06 |
|---|
