Hydrazine hydrate (1:1) → HCID 54088444, compound

Participants

Reaction Conditions

Reaction Steps

A 6.50 g (26.1 mmol) of ethyl (R)-4-t-butoxycarbonylamino-3-hydroxybutyrate (optical purity: 95%e.e.) was dissolved in 26 ml of methanol, and 1.96 g (39.1 mmol) of hydrazine monohydrate was added thereto dropwise at room temperature. After the addition, the mixture was heated to 65° C. and then stirred for 5 hours. After the mixture was cooled to room temperature, stirring was conducted overnight to give 4.27 g (70%) of the title compound. Melting point: 143.6° C. Optical purity: >99.9%e.e.

Provenance & Evidence