HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → (Z)-5-Fluoro-2-methyl-1-(3,4,5-trimethoxybenzylidene)-3-indenylacetyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | (Z)-5-fluoro-2-methyl-1-(3,4,5-trimethoxybenzylidene)-3-indenylacetic acid | HCID 9864863 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (Z)-5-Fluoro-2-methyl-1-(3,4,5-trimethoxybenzylidene)-3-indenylacetyl chloride | HCID 86755162 | — |
Reaction Steps
(Z)-5-fluoro-2-methyl-1-(3,4,5-trimethoxybenzylidene)-3-indenylaceticacid (20.64g, 54.70mmol) in THF (150 ml) is allowed to react with oxalylchloride (2 M in CH2Cl2; 35 ml; 70 mmol) under reflux conditions (24 h). The solvent is evaporated to yield the title compound, which is used as such in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06403831B1 |
| Source dataset | uspto-grants-2002_06 |
| ORD ID | ord-f05538304a5d4e7dbfe6ffd35743de16 |
| Source note | uspto-grants-2002_06 |