HRID218661

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11208318

1,2,3,4-Tetrahydro-5-(phenylmethoxy)-1-naphthalenecarboxylic acid

C18H18O3

HCID29282954

未命名化合物

PRODUCTS

生成物

结构：CCc1ccc(CN(C(=O)C2CCCc3c(OCc4ccccc4)cccc32)c2ccc(C(C)C)cc2)s1

HCID59597409

未命名化合物

收率 48.2%

PROCEDURE

实验过程

By the reaction and treatment in the same manner as in Example 12 using 5-benzyloxy-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid (1.13 g) and [(5-ethylthiophen-2-yl)methyl](4-isopropylphenyl)amine (1.04 g) as starting materials, 5-benzyloxy-N-[(5-ethylthiophen-2-yl)methyl]-N-(4-isopropylphenyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide (1.01 g) was obtained.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-de880209577a4e57b745e0042b4d8ac7
来源数据集: uspto-grants-2012_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08198454B2
来源说明: uspto-grants-2012_06

反应 SMILES

[CH2:1]([O:8][C:9]1[CH:18]=[CH:17][CH:16]=[C:15]2[C:10]=1[CH2:11][CH2:12][CH2:13][CH:14]2[C:19](O)=[O:20])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:22]([C:24]1[S:28][C:27]([CH2:29][NH:30][C:31]2[CH:36]=[CH:35][C:34]([CH:37]([CH3:39])[CH3:38])=[CH:33][CH:32]=2)=[CH:26][CH:25]=1)[CH3:23]>>[CH2:1]([O:8][C:9]1[CH:18]=[CH:17][CH:16]=[C:15]2[C:10]=1[CH2:11][CH2:12][CH2:13][CH:14]2[C:19]([N:30]([CH2:29][C:27]1[S:28][C:24]([CH2:22][CH3:23])=[CH:25][CH:26]=1)[C:31]1[CH:32]=[CH:33][C:34]([CH:37]([CH3:38])[CH3:39])=[CH:35][CH:36]=1)=[O:20])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1