Thiourea, 2-naphthalenyl- (9CI) → HCID 18537206, compound

Participants

Reaction Steps

Methyl 5-methylthio-4-[2-(2-naphthoylamino)(1,3-thiazol-4-yl)]thiophene-2-carboxylate hydrohromide: Methyl 4-(2-bromoacetyl)-5-methylthiothiophene-2-carboxylate (65 mg, 0.21 mmol) was allowed react with 2-napthylthiourea (42.4 mg) as described in Example 154, step (a) to give 82.5 mg (80% yield) of methyl 5-methylthio-4-[2-(2-naphthylamino)(1,3-thiazol-4-yl)]thiophene-2-carboxylate hydrobromide. 1H NMR (DMSO-d6, 300 MHz) δ 2.67 (s, 3H), 3.83 (s, 3 H), 7.31 (s, 1H), 7.50-7.67 (m, 4H), 7.93 (m, 1H), 8.15 (s, 1H), 8.31-8.35 (m, 1H), 8.46 (d, 1H, J=7.6), 10.22 (s, 1H)); Mass Spectrum (ESI) m/z calcd. for C20H16N2O2S3, 412.6 (M+H), found 413.1.

Provenance & Evidence