HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenylthiourea → Isopropyl 5-methyl-4-[2-(phenylamino)(1,3-thiazol-4-yl)]-thiophene-2-carboxylate hydrobromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenylthiourea | HCID 676454 | — |
| Reactant | Isopropyl 4-(2-bromoacetyl)-5-methylthiophene-2-carboxylate | HCID 18537306 | — |
| Reactant | Thiophene-2-carboxylate hydrobromide | HCID 86758185 | — |
| Product | Isopropyl 5-methyl-4-[2-(phenylamino)(1,3-thiazol-4-yl)]-thiophene-2-carboxylate hydrobromide | HCID 18537295 | 87% |
Reaction Steps
Isopropyl 5-methyl-4-[2-phenylamino)(1,3-thiazol-4-yl)]-thiophene-2-carboxylate hydrobromide: Isopropyl 4-(2-bromoacetyl)-5-methylthiophene-2-carboxylate (64 mg, 0.21 mmol) was allowed to react with phenylthiourea (32.1 mg) as described in Example 154, step (a) to give 80 mg (87% yield) of isopropyl 5-methyl-4-[2-(phenylamino)(1,3-thiazol-4-yl)]-thiophene-2-carboxylate hydrobromide. Mass Spectrum (ESI) m/z calcd. for C18H18N2O2S2, 358.5 (M+H), found 359.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06403633B2 |
| Source dataset | uspto-grants-2002_06 |
| ORD ID | ord-c7dc991ab51441a69e777b60068f4ca0 |
| Source note | uspto-grants-2002_06 |