HCID 17854226, compound → HCID 59597229, compound

HRID 218664Notes

Reaction equation

HRID 218664 reaction equation
[C:1]([C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[O:11][CH2:10][CH2:9][CH:8]2[C:13]([OH:15])=O)#[N:2].[CH3:16][N:17]([CH3:35])[C:18]1[CH:23]=[CH:22][C:21]([CH2:24][NH:25][C:26]2[CH:31]=[CH:30][C:29]([CH:32]([CH3:34])[CH3:33])=[CH:28][CH:27]=2)=[CH:20][CH:19]=1>>[C:1]([C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[O:11][CH2:10][CH2:9][CH:8]2[C:13]([N:25]([CH2:24][C:21]1[CH:20]=[CH:19][C:18]([N:17]([CH3:35])[CH3:16])=[CH:23][CH:22]=1)[C:26]1[CH:27]=[CH:28][C:29]([CH:32]([CH3:34])[CH3:33])=[CH:30][CH:31]=1)=[O:15])#[N:2]

Participants

3

Reactant 2

HCID 17854226HCID 17854226, compoundHCID 21957887N-(4-(Dimethylamino)benzyl)-4-isopropylbenzenamine

Product 1

HCID 59597229HCID 59597229, compoundYield 64.3%

Procedure

By the reaction and treatment in the same manner as in Example 12 using 8-cyanochroman-4-carboxylic acid (0.7 g) and [(4-dimethylaminophenyl)methyl](4-isopropylphenyl)amine (0.92 g) as starting materials, 8-cyano-N-[(4-dimethylaminophenyl)methyl]-N-(4-isopropylphenyl)chroman-4-carboxamide (1.0 g) was obtained. melting point: 178.8° C.

Sources & evidence

ORD record
ord-1856b903b0a34c17b4fdad74e2b46b2b
Source dataset
uspto-grants-2012_06
Patent number
US08198454B2

Reaction notes

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