Methanol → HCID 9861827, compound

Participants

Reaction Steps

A dry 100 ml 3-necked flask under nitrogen was charged with N-(3,4-dihydro-2H-benzothiopyran-4-yl)homopiperazine (1.0 g; 4.03 mmol) and treated sequentially with tetrahydrofuran (20 ml), methanol (10 ml), isoamyl aldehyde (5.0 ml; 46.0 mmol), sodium cyanoborohydride, (0.40 g; 6.4 mmol) and acetic acid (0.4 ml) as in Example 3. The resulting material was purified by kugelrohr distillation to give an oil (1.09 g), bp (air bath temperature) 150°-160° C. at 200 mtorr; 1H NMR (300 MHz, CD3OD) δ0.88-0.90 (d, 6H).

Provenance & Evidence