HCID 22449002, compound → HCID 21349907, compound

HRID 2186744Notes

Reaction equation

HRID 2186744 reaction equation
O[CH2:2][CH2:3][N:4]1[C:9]2[CH:10]=[CH:11][CH:12]=[C:13]([O:14][CH2:15][C:16]([O:18][CH3:19])=[O:17])[C:8]=2[O:7][CH2:6][CH2:5]1.[F:20][C:21]1[CH:26]=[CH:25][C:24]([C:27]([C:30]2[CH:35]=[CH:34][C:33]([F:36])=[CH:32][CH:31]=2)([SH:29])[CH3:28])=[CH:23][CH:22]=1>>[F:20][C:21]1[CH:26]=[CH:25][C:24]([C:27]([C:30]2[CH:31]=[CH:32][C:33]([F:36])=[CH:34][CH:35]=2)([S:29][CH2:2][CH2:3][N:4]2[C:9]3[CH:10]=[CH:11][CH:12]=[C:13]([O:14][CH2:15][C:16]([O:18][CH3:19])=[O:17])[C:8]=3[O:7][CH2:6][CH2:5]2)[CH3:28])=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 22449002HCID 22449002, compoundHCID 23086889HCID 23086889, compound

Product 1

HCID 21349907HCID 21349907, compoundYield 83.2%

Procedure

The same process as Example 1 was repeated except that methyl (4-(2-hydroxyethyl)-3,4-dihydro-2H-1,4-benzoxazin-8-yloxy)acetate (200 mg) and 1,1-bis-(4-fluorophenyl)ethanethiol (450 mg) were used to obtain the colorless oily object compound (311 mg, yield 83%).

Sources & evidence

ORD record
ord-34d7e895b3f441fe8b7b5c83bdf88a1a
Source dataset
uspto-grants-2002_06
Patent number
US06407096B1

Reaction notes

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