7-Methoxy-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid → HCID 59597224, compound

HRID 218676Notes

Reaction equation

HRID 218676 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH2:7][CH2:8][CH2:9][CH:10]2[C:13]([OH:15])=O)=[CH:5][CH:4]=1.[N:16]1([C:21]2[CH:26]=[CH:25][C:24]([CH2:27][NH:28][C:29]3[CH:34]=[CH:33][C:32]([CH:35]([CH3:37])[CH3:36])=[CH:31][CH:30]=3)=[CH:23][CH:22]=2)[CH:20]=[CH:19][N:18]=[CH:17]1>>[N:16]1([C:21]2[CH:22]=[CH:23][C:24]([CH2:27][N:28]([C:29]3[CH:30]=[CH:31][C:32]([CH:35]([CH3:37])[CH3:36])=[CH:33][CH:34]=3)[C:13]([CH:10]3[C:11]4[C:6](=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[CH:12]=4)[CH2:7][CH2:8][CH2:9]3)=[O:15])=[CH:25][CH:26]=2)[CH:20]=[CH:19][N:18]=[CH:17]1

Participants

3

Reactant 2

HCID 132774847-Methoxy-1,2,3,4-tetrahydronaphthalene-1-carboxylic acidHCID 67183963HCID 67183963, compound

Product 1

HCID 59597224HCID 59597224, compoundYield 30.9%

Procedure

By the reaction and treatment in the same manner as in Example 12 using 7-methoxy-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid (0.39 g) and {[4-(imidazol-1-yl)phenyl]methyl}(4-isopropylphenyl)amine (0.55 g) as starting materials, N-{[4-(imidazol-1-yl)phenyl]methyl}-N-(4-isopropylphenyl)-7-methoxy-1,2,3,4-tetrahydronaphthalene-1-carboxamide ½ hydrate (0.28 g) was obtained.

Sources & evidence

ORD record
ord-10a299c927f74ae797be3a008e11e91c
Source dataset
uspto-grants-2012_06
Patent number
US08198454B2

Reaction notes

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