1-Propanol → Ammonia

Participants

Reaction Steps

A suspension of sodium (25 mg, 1.1 mmol) in n-propanol (1 ml) was added to the title compound of example 6 (80 mg, 0.15 mmol) in n-propanol (1 ml), and the reaction mixture heated under reflux for 72 hours. Further sodium (100 mg, 4.34 mmol) and n-propanol (5 ml) were added portionwise over a further 48 hours, then the mixture cooled and evaporated under reduced pressure. The residue was purified by preparative thin layer chromatography on silica gel, using dichloromethane:methanol:0.88 ammonia (95:5:0.5) as eluant, to afford the title compound, (8 mg).

Provenance & Evidence