4-amino-N,N-diethylbenzene-1-sulfonamide → 2-Phenyl-2-pyridin-4-yl-acetamide

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Reaction Steps

As described in Example 1, 4-Amino-N,N-diethyl-benzenesulfonamide (242 mg, 1.06 mmol, 2.0 equiv) was coupled with phenyl-pyridin-4-yl-acetic acid ethyl ester (128 mg, 0.53 mmol, 1.0 equiv) using trimethylaluminum (0.53 mL, 0.53 mmol, 2 equiv) in dichloroethane (20 mL). Standard work-up and purification of the residue by rotary chromatography (5% methanol/methylene chloride) provided N-(4-Diethylsulfamoyl-phenyl)-2-phenyl)-2-phenyl-2-pyridin-4-yl-acetamide (337 mg)

Provenance & Evidence