HuagongsheHuagongshe Chemistry Print Report · For research reference only
7-Methoxy-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid → N-[(5-ethylthiophen-2-yl)methyl]-N-(4-isopropylphenyl)-7-methoxy-1,2,3,4-tetrahydronaphthalene-1-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 7-Methoxy-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid | HCID 13277484 | — |
| Reactant | [(5-Ethylthiophen-2-yl)methyl](4-isopropylphenyl)amine | HCID 29282954 | — |
| Product | N-[(5-ethylthiophen-2-yl)methyl]-N-(4-isopropylphenyl)-7-methoxy-1,2,3,4-tetrahydronaphthalene-1-carboxamide | HCID 59597319 | 14.6% |
Reaction Steps
By the reaction and treatment in the same manner as in Example 12 using 7-methoxy-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid (0.82 g) and [(5-ethylthiophen-2-yl)methyl](4-isopropylphenyl)amine (1.04 g) as starting materials, N-[(5-ethylthiophen-2-yl)methyl]-N-(4-isopropylphenyl)-7-methoxy-1,2,3,4-tetrahydronaphthalene-1-carboxamide (0.26 g) was obtained. MS (ESI)m/z: 448 [MH]+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08198454B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-474b3d09f13049a7acad1a2cb669021d |
| Source note | uspto-grants-2012_06 |