5-Benzyloxy-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid → HCID 17854142, compound

HRID 218679Notes

Reaction equation

HRID 218679 reaction equation
[CH2:1]([O:8][C:9]1[CH:18]=[CH:17][CH:16]=[C:15]2[C:10]=1[CH2:11][CH2:12][CH2:13][CH:14]2[C:19](O)=[O:20])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[N:22]1([C:27]2[CH:32]=[CH:31][C:30]([CH2:33][NH:34][C:35]3[CH:40]=[CH:39][C:38]([CH:41]([CH3:43])[CH3:42])=[CH:37][CH:36]=3)=[CH:29][CH:28]=2)[CH:26]=[CH:25][N:24]=[CH:23]1>>[CH2:1]([O:8][C:9]1[CH:18]=[CH:17][CH:16]=[C:15]2[C:10]=1[CH2:11][CH2:12][CH2:13][CH:14]2[C:19]([N:34]([CH2:33][C:30]1[CH:29]=[CH:28][C:27]([N:22]2[CH:26]=[CH:25][N:24]=[CH:23]2)=[CH:32][CH:31]=1)[C:35]1[CH:36]=[CH:37][C:38]([CH:41]([CH3:43])[CH3:42])=[CH:39][CH:40]=1)=[O:20])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 112083185-Benzyloxy-1,2,3,4-tetrahydronaphthalene-1-carboxylic acidHCID 67183963HCID 67183963, compound

Product 1

HCID 17854142HCID 17854142, compoundYield 59.1%

Procedure

By the reaction and treatment in the same manner as in Example 12 using 5-benzyloxy-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid (0.54 g) and {[4-(imidazol-1-yl)phenyl]methyl}(4-isopropylphenyl)amine (0.55 g) as starting materials, 5-benzyloxy-N-{[4-(imidazol-1-yl)phenyl]methyl-}-N-(4-isopropylphenyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide (0.62 g) was obtained.

Sources & evidence

ORD record
ord-840700f0a33b47309b56133a5de4b7d3
Source dataset
uspto-grants-2012_06
Patent number
US08198454B2

Reaction notes

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