Bromine → HCID 9865579, compound

HRID 2186799Notes

Reaction equation

HRID 2186799 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([OH:25])[CH:9]([N:12]2[CH2:17][CH2:16][CH:15]([CH2:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH2:14][CH2:13]2)[CH2:10][OH:11])=[CH:4][CH:3]=1.[C:26]([S-:28])#[N:27].[K+].BrBr>C(O)(=O)C>[OH:11][CH2:10][CH:9]([N:12]1[CH2:13][CH2:14][CH:15]([CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH2:16][CH2:17]1)[CH:8]([OH:25])[C:5]1[CH:6]=[CH:7][C:2]2[N:1]=[C:26]([NH2:27])[S:28][C:3]=2[CH:4]=1

Participants

5

Reactant 3

HCID 24408BromineHCID 516872Potassium thiocyanateHCID 131723307HCID 131723307, compound

Product 1

HCID 9865579HCID 9865579, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent2×

Procedure

To a stirred solution of 5 g of (+) three 1-p-aminophenyl-2-(4-benzylpiperidin-1-yl)-1,3 propandiol and 5.7 g of KSCN in 30 ml of glacial acetic acid was added dropwise a solution of 2.36 g of Br2 in 25 ml of glacial acetic acid at room temperature.

Sources & evidence

ORD record
ord-7f19405b48aa49cd81461e93be55287e
Source dataset
uspto-grants-2002_06
Patent number
US06407122B1

Reaction notes

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