HCID 9956521, compound → HCID 9826045, compound

HRID 2186807Notes

Reaction equation

HRID 2186807 reaction equation
[O:1]([CH2:8][CH:9]([N:22]1[CH2:27][CH2:26][CH:25]([CH2:28][C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH2:24][CH2:23]1)[CH:10]([OH:21])[C:11]1[CH:20]=[CH:19][C:14]2[N:15]=[C:16]([NH2:18])[S:17][C:13]=2[CH:12]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>ClCCl>[NH2:18][C:16]1[S:17][C:13]2[CH:12]=[C:11]([C:10](=[O:21])[CH:9]([N:22]3[CH2:27][CH2:26][CH:25]([CH2:28][C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=4)[CH2:24][CH2:23]3)[CH2:8][O:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)[CH:20]=[CH:19][C:14]=2[N:15]=1

Participants

3

Reactant 1

HCID 9956521HCID 9956521, compound

Product 1

HCID 9826045HCID 9826045, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

After stirring for 20 min., a solution of 3 g of (±) threo 1-phenoxymethyl-1-(4-benzylpiperidin-1-yl)-2-hydroxy-2-(2-aminobenzothiazol-6-yl)-ethane in 30 ml of dichloromethane was slowly added dropwise and the resulting cloudy solution was stirred for 20 min.

Workup

  1. stirringthe resulting cloudy solution was stirred for 20 min.

Sources & evidence

ORD record
ord-e90f4cb06f4f4af096ab924b49c1dd7b
Source dataset
uspto-grants-2002_06
Patent number
US06407122B1

Reaction notes

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