Sodium Carbonate → HCID 22449418, compound

Participants

Reaction Conditions

Reaction Steps

102 mg of the compound prepared in (4) above was charged into 20 ml of 3 N hydrochloric acid aqueous solution, and the mixture was heated at 60° C. for 2 hours while stirring. After cooling to 0° C., the reaction mixture was neutralized with sodium carbonate and extracted with chloroform. The extract was dried over magnesium sulfate, and subjected to silica gil column chromatography using an chloroform-methanol (40:1) mixed solvent as an eluant to obtain fractions containing the target compound. The fractions were concentrated to produce 66 mg of the title compound.

Provenance & Evidence