Sodium Hydroxide → HCID 22449527, compound

Participants

Reaction Conditions

Reaction Steps

109 mg of the compound prepared in (1) above was added to 10 ml of 6 N hydrochloric acid, and the mixture was stirred at 90° C. for 20 minutes. After cooling, the mixture was alkalinized by the addition of sodium hydroxide and extracted with chloroform. The chloroform layer was dried over anhydrous sodium sulfate. The residue obtained after removal of the solvent was subjected to silica gel column chromatography using a chloroform-ethyl acetate (4:1) mixed solvent as an eluant to obtain fractions containing the target compound. The fractions were concentrated to produce 51 mg of the title compound. p NMR(CDCl3) δ: 2.09(3H, s), 2.16(3H, s), 2.98(1H, m), 3.60(1H, m), 4.6-5.0(1H, m), 6.33(1H, d, J=9 Hz), 7.02(1H, d, J=9 Hz).

Provenance & Evidence