2,8-Diacetylamino-1-tetralone → 2-Acetylamino-8-amino-5-methyl-1-tetralone

HRID 2186855Notes

Reaction equation

HRID 2186855 reaction equation
[C:1]([NH:4][CH:5]1[CH2:14][CH2:13][C:12]2[C:7](=[C:8]([NH:16]C(=O)C)[CH:9]=[CH:10][C:11]=2[CH3:15])[C:6]1=[O:20])(=[O:3])[CH3:2].C(NC1CCC2C(=C(NC(=O)C)C=CC=2)C1=O)(=O)C>>[C:1]([NH:4][CH:5]1[CH2:14][CH2:13][C:12]2[C:7](=[C:8]([NH2:16])[CH:9]=[CH:10][C:11]=2[CH3:15])[C:6]1=[O:20])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 120472982,8-Diacetylamino-1-tetraloneHCID 867509612,8-Diacetylamino-5-methyl-1-tetralone

Product 1

HCID 224494492-Acetylamino-8-amino-5-methyl-1-tetralone

Procedure

The reaction was carried out in the same manner as in Example 1-(4), except that 400 mg of the compound prepared in (7) above was used instead of 2,8-diacetylamino-1-tetralone of Example 1-(4), and post-treated to produce 265 mg of the title compound.

Workup

  1. additionpost-treated

Sources & evidence

ORD record
ord-eb6c3450dacb4a82a543759025f5d348
Source dataset
uspto-grants-2002_06
Patent number
US06407115B1

Reaction notes

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