1-Acetylamino-6,7,8,9-tetrahydro-5H-benzocycloheptene-9-one → 1,8-Diacetylamino-6,7,8,9-tetrahydro-5H-benzocycloheptene-9-one

HRID 2186858Notes

Reaction equation

HRID 2186858 reaction equation
[C:1]([NH:4][C:5]1[C:10]2[C:11](=[O:16])[CH2:12][CH2:13][CH2:14][CH2:15][C:9]=2[CH:8]=[CH:7][CH:6]=1)(=[O:3])[CH3:2].[C:17]([NH:20]C1C=CC=C2C=1C(=O)CCC2)(=[O:19])[CH3:18]>>[C:1]([NH:4][C:5]1[C:10]2[C:11](=[O:16])[CH:12]([NH:20][C:17](=[O:19])[CH3:18])[CH2:13][CH2:14][CH2:15][C:9]=2[CH:8]=[CH:7][CH:6]=1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 103532981-Acetylamino-6,7,8,9-tetrahydro-5H-benzocycloheptene-9-oneHCID 12119265N-(8-Oxo-5,6,7,8-tetrahydronaphthalen-1-YL)acetamide

Product 1

HCID 224494531,8-Diacetylamino-6,7,8,9-tetrahydro-5H-benzocycloheptene-9-one

Procedure

The reaction was carried out in the same manner as in Example 1-(2), except that 270 mg of the compound prepared in (2) above was used instead of 8-acetylamino-1-tetralone of Example 1-(2). The reaction mixture obtained by the post-treatment was further reacted in the same manner as in Example 1-(3) and post-treated to produce 126 mg of the title compound.

Workup

  1. customThe reaction mixture obtained by the post-treatment
  2. additionpost-treated

Sources & evidence

ORD record
ord-b3a14e61c6d043cf99a538625fce41ec
Source dataset
uspto-grants-2002_06
Patent number
US06407115B1

Reaction notes

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