N-(8-Oxo-5,6,7,8-tetrahydronaphthalen-1-YL)acetamide → 1-Acetyl-3,5-diacetylamino-8-chloro-2,3-dihydro-quinoline-4-one

HRID 2186863Notes

Reaction equation

HRID 2186863 reaction equation
[C:1]([N:4]1[C:13]2[C:8](=[C:9]([NH:15][C:16](=[O:18])[CH3:17])[CH:10]=[CH:11][C:12]=2[Cl:14])[C:7](=[O:19])[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[C:20]([NH:23]C1C=CC=C2C=1C(=O)CCC2)(=[O:22])[CH3:21]>>[C:1]([N:4]1[C:13]2[C:8](=[C:9]([NH:15][C:16](=[O:18])[CH3:17])[CH:10]=[CH:11][C:12]=2[Cl:14])[C:7](=[O:19])[CH:6]([NH:23][C:20](=[O:22])[CH3:21])[CH2:5]1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 12119265N-(8-Oxo-5,6,7,8-tetrahydronaphthalen-1-YL)acetamideHCID 224494211-Acetyl-5-acetylamino-8-chloro-2,3-dihydroquinoline-4-one

Product 1

HCID 224495101-Acetyl-3,5-diacetylamino-8-chloro-2,3-dihydro-quinoline-4-one

Procedure

The reaction was carried out in the same manner as in Example 1-(2), except that 1.4 gm of the compound prepared in (1) above was used instead of 8-acetylamino-1-tetralone of Example 1-(2). The reaction mixture obtained by the post-treatment was further reacted in the same manner as in Example 1-(3) and post-treated to produce 0.62 gm of the title compound.

Workup

  1. customThe reaction mixture obtained by the post-treatment
  2. additionpost-treated

Sources & evidence

ORD record
ord-0386d02755a844c3848777d63090ac10
Source dataset
uspto-grants-2002_06
Patent number
US06407115B1

Reaction notes

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