Hydrochloric Acid → 4-(4-Fluoro-3-methylphenyl)-4-oxobutanoic acid

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Reaction Conditions

Reaction Steps

200 gm of succinic anhydride and 800 gm of aluminum chloride were added to 250 ml of 2-fluorotoluene, and the mixture was heated at 80° C. for 1 hour. Upon the addition of 5 l of 1% cold hydrochloric acid aqueous solution, the reaction mixture was extracted with ethyl acetate, washed with 1 N hydrochloric acid and water, and dried over anhydrous sodium sulfate. The solvent was evaporated to obtain 345 gm of the title compound. NMR(CDCl3) δ: 1.89-1.97(2H, m), 2.24(3H, s), 2.36(2H, t, J=7.3 Hz), 2.60(2H, t, J=7.3 Hz), 6.84-6.99(3H, m).

Provenance & Evidence