Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 2-(4-Aminophenyl)-1H-isoindole-1,3(2H)-dione | HCID 617138 | — |
| Reactant | Lithium borohydride | HCID 4148881 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 18543597 | HCID 18543597 | — |
Reaction Steps
To a solution of N-(4-aminophenyl)phthalimide (332 mg) in tetrahydrofuran (4 mL) is added lithium borohydride (1.0 g) and the mixture is stirred for 1 hour at 250° C. The mixture is poured into water and extracted into ethyl acetate. The ethyl acetate solution is dried over anhydrous sodium sulfate and concentrated under reduced pressure to give a white foam, which when triturated with diethyl ether provides the desired product as a white powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06407123B1 |
|---|
| Source dataset | uspto-grants-2002_06 |
|---|
| ORD ID | ord-63c25e04485e4b5d8073df42f74e57ce |
|---|
| Source note | uspto-grants-2002_06 |
|---|
