4-(Chloromethyl)-2-methyl-1,3-thiazole → HCID 67952255, compound

HRID 218699Notes

Reaction equation

HRID 218699 reaction equation
[CH2:1]([O:8][C:9]1([C:19]([NH:21][C:22]2[CH:27]=[CH:26][C:25]([O:28][CH3:29])=[CH:24][CH:23]=2)=[O:20])[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH2:12][CH2:11][CH2:10]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[CH2:31][C:32]1[N:33]=[C:34]([CH3:37])[S:35][CH:36]=1>>[CH2:1]([O:8][C:9]1([C:19]([N:21]([C:22]2[CH:27]=[CH:26][C:25]([O:28][CH3:29])=[CH:24][CH:23]=2)[CH2:31][C:32]2[N:33]=[C:34]([CH3:37])[S:35][CH:36]=2)=[O:20])[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH2:12][CH2:11][CH2:10]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 7363414-(Chloromethyl)-2-methyl-1,3-thiazoleHCID 67952245HCID 67952245, compound

Product 1

HCID 67952255HCID 67952255, compoundYield 78.9%

Procedure

By the reaction and treatment in the same manner as in Example 132 using 5 benzyloxy -N-(4-methoxyphenyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide (0.63 g) and 4-(chloromethyl)-2-methylthiazole (0.30 g) as starting materials, 5 benzyloxy-N-(4-methoxyphenyl)-N-[(2-methylthiazol-4-yl)methyl]-1,2,3,4-tetrahydronaphthalene-1-carboxamide (0.64 g) was obtained. By the reaction and treatment in the same manner as in Example 133 using this compound (0.50 g), 5-hydroxy-N-(4-methoxyphenyl)-N-1(2-methylthiazol-4-yl)methyl]-1,2,3,4-tetrahydronaphthalene-1-carboxamide (0.31 g) was obtained.

Sources & evidence

ORD record
ord-b39ec307e7c946cf91f513773d0908eb
Source dataset
uspto-grants-2012_06
Patent number
US08198454B2

Reaction notes

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