4-Methoxy-2,3-dihydro-1H-indene-1-carboxylic acid → HCID 59597324, compound

HRID 218703Notes

Reaction equation

HRID 218703 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:4]=1[CH2:5][CH2:6][CH:7]2[C:12]([OH:14])=O.[CH2:15]([N:17]1[CH:21]=[C:20]([CH2:22][NH:23][C:24]2[CH:29]=[CH:28][C:27]([CH:30]([CH3:32])[CH3:31])=[CH:26][CH:25]=2)[CH:19]=[N:18]1)[CH3:16]>>[CH2:15]([N:17]1[CH:21]=[C:20]([CH2:22][N:23]([C:24]2[CH:25]=[CH:26][C:27]([CH:30]([CH3:31])[CH3:32])=[CH:28][CH:29]=2)[C:12]([CH:7]2[C:8]3[C:4](=[C:3]([O:2][CH3:1])[CH:11]=[CH:10][CH:9]=3)[CH2:5][CH2:6]2)=[O:14])[CH:19]=[N:18]1)[CH3:16]

Participants

3

Reactant 2

HCID 198826244-Methoxy-2,3-dihydro-1H-indene-1-carboxylic acidHCID 21957909N-((1-Ethyl-1H-pyrazol-4-yl)methyl)-4-isopropylaniline

Product 1

HCID 59597324HCID 59597324, compoundYield 61.9%

Procedure

By the reaction and treatment in the same manner as in Example 12 using 4-methoxyindan-1-carboxylic acid (0.29 g) and [(1-ethylpyrazol-4-yl)methyl](4-isopropylphenyl)amine (0.37 g) as starting materials, N-[(1-ethylpyrazol-4-yl)methyl]-N-(4-isopropylphenyl)-4-methoxyindan-1-carboxamide (0.39 g) was obtained.

Sources & evidence

ORD record
ord-fcac02c9cfde4ba3968c0f0f7d4fd717
Source dataset
uspto-grants-2012_06
Patent number
US08198454B2

Reaction notes

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