Acetic Acid Mixture with Hydrobromic Acid → HCID 131723311, compound

HRID 2187034Notes

Reaction equation

HRID 2187034 reaction equation
[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:10]([NH:12][C@H:13]([C:18]([NH:20][C:21]1[CH:29]=[CH:28][C:24]([N+:25]([O-:27])=[O:26])=[CH:23][CH:22]=1)=[O:19])[CH2:14][CH2:15][CH2:16][CH3:17])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.Br.C(O)(=O)C>>[NH2:1][C@H:2]([C:10]([NH:12][C@H:13]([C:18]([NH:20][C:21]1[CH:22]=[CH:23][C:24]([N+:25]([O-:27])=[O:26])=[CH:28][CH:29]=1)=[O:19])[CH2:14][CH2:15][CH2:16][CH3:17])=[O:11])[CH2:3][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

Participants

3

Reactant 2

HCID 21893785Acetic Acid Mixture with Hydrobromic AcidHCID 131723312HCID 131723312, compound

Product 1

HCID 131723311HCID 131723311, compound

Procedure

A solution of CbzPheNle-pNA (prepared in 2 (1); 51 mg) in 30%HBr-acetic acid was stirred for 30 minutes. The solvent was distilled off under reduced pressure. The reaction mixture was dissolved into anhydrous DMF (2 ml). N(Et)3 (0.013 ml) was added dropwise thereto to obtain PheNle-pNA.Et4NHBr.

Workup

  1. distillationThe solvent was distilled off under reduced pressure
  2. dissolutionThe reaction mixture was dissolved into anhydrous DMF (2 ml)
  3. additionN(Et)3 (0.013 ml) was added dropwise

Sources & evidence

ORD record
ord-8c927bd2597142bba75f7b6ad5f8ffa9
Source dataset
uspto-grants-2002_06
Patent number
US06407206B1

Reaction notes

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