Sodium Hydroxide → HCID 22449317, compound

Participants

Reaction Steps

(RS)-2a-(3-ethoxycarbonylpropyl)-2a,3,4,5-tetrahydro-1H-benz[cd]indol-2-one (6.20 g, 21.6 mmol) was dissolved in dimethoxyethane (70 ml). Then, 1N sodium hydroxide solution (22 ml, 22 mmol) was added thereto to effect a reaction at 25° C. for 18 hours. Successively the resulting solution was concentrated and aqueous hydrochloric acid was added to the residue obtained to effect crystallization, followed by filtration. Thus, the crystal was obtained in an amount of 5.45 g (yield 97%). MW 259.30 (C15H17NO3); mass spectrum EIMS m/z 259(M)+

Provenance & Evidence