反应详情

9-methylcarbamoylmethyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole•trifluoroacetate (450 mg, 1.26 mmol) and (S)-(4-bromobutyl)-2a,3,4,5-tetrahydro-1H-benz[cd]indol-2-one (308 mg, 1.0 mmol) were dissolved in dimethylformamide (5 ml). Then triethylamine(0.9 ml, 6 mmol) was added thereto. The resulting solution was reacted at room temperature for 3 days. To the reaction mixture obtained was added ethyl acetate (50 ml), which was then washed with water (50 ml×2) and saturated saline solution, successively dried with anhydrous sodium sulfate. The ethyl acetate solution was concentrated under reduced pressure to obtain a crude reaction product, which was purifiedbymeans of silica gel column chromatography, whereby 376 mg (yield 80%) of the above-described object compound could be obtained.

1. customThe resulting solution was reacted at room temperature for 3 days
2. customTo the reaction mixture obtained
3. washwas then washed with water (50 ml×2) and saturated saline solution
4. dry with materialsuccessively dried with anhydrous sodium sulfate
5. concentrationThe ethyl acetate solution was concentrated under reduced pressure
6. customto obtain a crude
7. customreaction product, which