HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isatoic Anhydride → 2-Amino-N-[4-(4-diphenylmethoxypiperidino)butyl]benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isatoic Anhydride | HCID 8359 | — |
| Reactant | 1-Piperidinebutanamine, 4-(diphenylmethoxy)- | HCID 11739259 | — |
| Product | 2-Amino-N-[4-(4-diphenylmethoxypiperidino)butyl]benzamide | HCID 22449701 | 100% |
Reaction Steps
Using the method similar to that in Reference Example 1 and using 1-(4-aminobutyl)-4-diphenylmethoxypiperidine instead of 4-methoxybenzylamine and starting from isatoic anhydride (3.18 g), the title compound (9.14 g, about 100%) was synthesized. Recrystallization from ethyl acetate-isopropyl ether yielded a colorless crystal, melting point 74.0 to 75.0° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06407116B1 |
| Source dataset | uspto-grants-2002_06 |
| ORD ID | ord-3ef4fecfb00c47f8b7d14cb494406caf |
| Source note | uspto-grants-2002_06 |