3-[(3-Methoxycarbonylphenyl)methyl]-2,4-dioxo-1-[4-(4-diphenylmethoxypiperidino)butyl]-1,2,3,4-tetrahydroquinazoline → HCID 22449684, compound

HRID 2187070Notes

Reaction equation

C[O:2][C:3]([C:5]1[CH:6]=[C:7]([CH2:11][N:12]2[C:21](=[O:22])[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[N:14]([CH2:23][CH2:24][CH2:25][CH2:26][N:27]3[CH2:32][CH2:31][CH:30]([O:33][CH:34]([C:41]4[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=4)[C:35]4[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=4)[CH2:29][CH2:28]3)[C:13]2=[O:47])[CH:8]=[CH:9][CH:10]=1)=[O:4].[ClH:48].COC(C1C=C(CN2C(=O)C3C(=CC=CC=3)N(CCCCN3CCC(OC(C4C=CC=CC=4)C4C=CC=CC=4)CC3)C2=O)C=CC=1)=O>>[ClH:48].[C:3]([C:5]1[CH:6]=[C:7]([CH2:11][N:12]2[C:21](=[O:22])[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[N:14]([CH2:23][CH2:24][CH2:25][CH2:26][N:27]3[CH2:28][CH2:29][CH:30]([O:33][CH:34]([C:35]4[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=4)[C:41]4[CH:42]=[CH:43][CH:44]=[CH:45][CH:46]=4)[CH2:31][CH2:32]3)[C:13]2=[O:47])[CH:8]=[CH:9][CH:10]=1)([OH:4])=[O:2]

Participants

Reactant 2

HCID 224496793-[(3-Methoxycarbonylphenyl)methyl]-2,4-dioxo-1-[4-(4-diphenylmethoxypiperidino)butyl]-1,2,3,4-tetrahydroquinazoline

HCID 22449799HCID 22449799, compound

Product 1

HCID 22449684HCID 22449684, compoundYield 88%

Procedure

Using the method similar to that in Example 65 and starting from 3-[(3-methoxycarbonylphenyl)methyl]-2,4-dioxo-1-[4-(4-diphenylmethoxypiperidino)butyl]-1,2,3,4-tetrahydroquinazoline (0.38 g, 0.60 mmol) which is a free salt of the compound obtained in Example 63, the title compound (0.36 g, 88%) was obtained.

Sources & evidence

ORD record: ord-ee4d6d1cf6e24933b6d3d08462b0cf1f
Source dataset: uspto-grants-2002_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06407116B1

Reaction notes

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