Methanesulfonyl chloride → HCID 22449872, compound

Participants

Reaction Steps

Using the method similar to that in Example 43 and methanesulfonyl chloride (190 ml, 2.45 mmol) instead of ethylmalonyl chloride and starting from 6-amino-2,4-dioxo-1-[4-(4-diphenylmethoxypiperidino)butyl]-1,2,3,4-tetrahydroquinazoline (1.02 g, 2.05 mmol) obtained in Example 40, a free salt of the title compound (681 mg, 58%) was synthesized. Recrystallization from ethyl acetate yielded a colorless crystal having a melting point of 204 to 205° C.

Provenance & Evidence