Ethyl N-methylaminoacetate hydrochloride → HCID 22449800, compound

HRID 2187081Notes

Reaction equation

HRID 2187081 reaction equation
[O:1]=[C:2]1[N:11]([CH2:12][C:13]([OH:15])=O)[C:10](=[O:16])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]1[CH2:17][CH2:18][CH2:19][CH2:20][N:21]1[CH2:26][CH2:25][CH:24]([O:27][CH:28]([C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH2:23][CH2:22]1.[ClH:41].[CH2:42]([O:44][C:45](=[O:49])[CH2:46][NH:47][CH3:48])[CH3:43]>>[ClH:41].[O:1]=[C:2]1[N:11]([CH2:12][C:13]([N:47]([CH2:46][C:45]([O:44][CH2:42][CH3:43])=[O:49])[CH3:48])=[O:15])[C:10](=[O:16])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]1[CH2:17][CH2:18][CH2:19][CH2:20][N:21]1[CH2:26][CH2:25][CH:24]([O:27][CH:28]([C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=2)[CH2:23][CH2:22]1

Participants

3

Reactant 2

HCID 171173Ethyl N-methylaminoacetate hydrochlorideHCID 17795908HCID 17795908, compound

Product 1

HCID 22449800HCID 22449800, compoundYield 83%

Procedure

Using the method similar to that in Example 109 and starting from 2,4-dioxo-1-[4-(4-diphenylmethoxypiperidino)butyl]-1,2,3,4-tetrahydroquinazoline-3-acetic acid (1.20 g, 2.22 mmol) obtained in Example 50, and also using sarcosine ethyl ester hydrochloride (408 mg, 2.66 mmol) instead of glycine methyl ester hydrochloride, the ethyl ester of the title compound (1.19 g 83%) was obtained as an oil.

Sources & evidence

ORD record
ord-33ebc87fc757421aa3ed6aa83b0cd7f9
Source dataset
uspto-grants-2002_06
Patent number
US06407116B1

Reaction notes

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