beta-Alanine, ethyl ester, hydrochloride → HCID 22449696, compound

HRID 2187082Notes

Reaction equation

HRID 2187082 reaction equation
[O:1]=[C:2]1[N:11]([CH2:12][C:13]([OH:15])=O)[C:10](=[O:16])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]1[CH2:17][CH2:18][CH2:19][CH2:20][N:21]1[CH2:26][CH2:25][CH:24]([O:27][CH:28]([C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH2:23][CH2:22]1.[ClH:41].[CH2:42]([O:44][C:45](=[O:49])[CH2:46][CH2:47][NH2:48])[CH3:43]>>[ClH:41].[O:1]=[C:2]1[N:11]([CH2:12][C:13]([NH:48][CH2:47][CH2:46][C:45]([O:44][CH2:42][CH3:43])=[O:49])=[O:15])[C:10](=[O:16])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]1[CH2:17][CH2:18][CH2:19][CH2:20][N:21]1[CH2:26][CH2:25][CH:24]([O:27][CH:28]([C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=2)[C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[CH2:23][CH2:22]1

Participants

3

Reactant 2

HCID 458475beta-Alanine, ethyl ester, hydrochlorideHCID 17795908HCID 17795908, compound

Product 1

HCID 22449696HCID 22449696, compoundYield 70.5%

Procedure

Using the method similar to that in Example 109 and starting from 2,4-dioxo-1-[4-(4-diphenylmethoxypiperidino)butyl]-1,2,3,4-tetrahydroquinazoline-3-acetic acid (1.20 g, 2.22 mmol) obtained in Example 50, and also using b-alanine ethyl ester hydrochloride (408 mg, 2.66 mmol) instead of glycine methyl ester hydrochloride, the ethyl ester of the title compound (1.06 g 65%) was obtained as an oil.

Sources & evidence

ORD record
ord-a54fb68249f74bfba6baaf6d8124900f
Source dataset
uspto-grants-2002_06
Patent number
US06407116B1

Reaction notes

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