HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloro-2-(phenylsulfonyl)-5-(trifluoromethyl)pyridine → 2-(4-Chloro-2-fluoro-5-methoxyphenyl)-3-chloro-5-trifluoromethylpyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloro-2-(phenylsulfonyl)-5-(trifluoromethyl)pyridine | HCID 1479266 | — |
| Reactant | HCID 178492975 | HCID 178492975 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-(4-Chloro-2-fluoro-5-methoxyphenyl)-3-chloro-5-trifluoromethylpyridine | HCID 11002295 | 84% |
Reaction Steps
3-Chloro-2-phenylsulfonyl-5-trifluoromethylpyridine was stirred with 4-chloro-2-fluoro-5-methoxyphenylmagnesium bromide for 2.5 hours at room temperature in THF. Working-up by distillation gave the coupling product 2-(4-chloro-2-fluoro-5-methoxyphenyl)-3-chloro-5-trifluoromethylpyridine in a yield of 84%, which is outstanding.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06407245B2 |
| Source dataset | uspto-grants-2002_06 |
| ORD ID | ord-1db5714982bc480a8c3fc46735997310 |
| Source note | uspto-grants-2002_06 |