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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2187102Generated: October 25, 2026

(3S,4S)-4-[2-(4-benzyl-3-hydroxy-piperidin-1-yl)-ethanesulfonyl]-phenol → 3-[(tert-Butoxycarbonyl-methyl-amino)-methyl]-benzoic Acid (3S,4S)-4-[2-(4-benzyl-3-hydroxy-piperidin-1-yl)-ethanesulfonyl]-phenyl Ester

https://huagongshe.com/reaction/2187102

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(3S,4S)-4-[2-(4-benzyl-3-hydroxy-piperidin-1-yl)-ethanesulfonyl]-phenolHCID 9885963—
Reactant3-[(Tert-butoxycarbonyl-methyl-amino)-methyl]-benzoic acidHCID 22450243—
Product3-[(tert-Butoxycarbonyl-methyl-amino)-methyl]-benzoic Acid (3S,4S)-4-[2-(4-benzyl-3-hydroxy-piperidin-1-yl)-ethanesulfonyl]-phenyl EsterHCID 8658479870%

Reaction Steps

The title compound was prepared from (3S,4S)-4-[2-(4-benzyl-3-hydroxy-piperidin-1-yl)-ethanesulfonyl]-phenol and 3-[(tert-butoxycarbonyl-methyl-amino)-methyl]-benzoic acid in 70% yield as a colorless gum.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06407235B1
Source datasetuspto-grants-2002_06
ORD IDord-4ab49c6b536541f390b97714f5c0745f
Source noteuspto-grants-2002_06