2-Propoxy-5-iodonicotinic acid → HCID 11532334, compound

HRID 2187123Notes

Reaction equation

HRID 2187123 reaction equation
[CH2:1]([O:4][C:5]1[N:13]=[CH:12][C:11]([I:14])=[CH:10][C:6]=1[C:7]([OH:9])=O)[CH2:2][CH3:3].[NH2:15][C:16]1[C:17]([CH2:24][CH3:25])=[N:18][NH:19][C:20]=1[C:21]([NH2:23])=[O:22]>>[NH2:23][C:21]([C:20]1[C:16]([NH:15][C:7](=[O:9])[C:6]2[CH:10]=[C:11]([I:14])[CH:12]=[N:13][C:5]=2[O:4][CH2:1][CH2:2][CH3:3])=[C:17]([CH2:24][CH3:25])[NH:18][N:19]=1)=[O:22]

Participants

3

Reactant 2

HCID 116380942-Propoxy-5-iodonicotinic acidHCID 178438044HCID 178438044, compound

Product 1

HCID 11532334HCID 11532334, compound

Procedure

The title compound was prepared from 2-propoxy-5-iodonicotinic acid (see Preparation 2(h) and 4-amino-3-ethyl-1H-pyrazole-5-carboxamide (prepared as described in WO 98/49166) according to the method described in Preparation 2(g)(i).

Workup

  1. customdescribed in Preparation 2(g)(i)

Sources & evidence

ORD record
ord-b0cb0fffc74e4fa7afb036a763762dc0
Source dataset
uspto-grants-2002_06
Patent number
US06407259B1

Reaction notes

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