Methyl 6-methylnicotinate → (6-Methylpyridin-3-yl)methanol

HRID 2187214Notes

Reaction equation

HRID 2187214 reaction equation
[CH3:1][C:2]1[CH:11]=[CH:10][C:5]([C:6](OC)=[O:7])=[CH:4][N:3]=1.ClC1C=CC(C(OC)=O)=CN=1>>[CH3:1][C:2]1[N:3]=[CH:4][C:5]([CH2:6][OH:7])=[CH:10][CH:11]=1

Participants

3

Reactant 2

HCID 231548Methyl 6-methylnicotinateHCID 254249Methyl 6-chloropyridine-3-carboxylate

Product 1

HCID 11228788(6-Methylpyridin-3-yl)methanol

Procedure

The reaction procedure of Reference Example 20 (3) was repeated except that methyl 6-methylnicotinate was used in lieu of methyl 6-chloronicotinate to give crude 6-methyl-3-pyridylmethanol as a yellow oil.

Sources & evidence

ORD record
ord-60db5055845d4f9ca492c2d7c0f9f63f
Source dataset
uspto-grants-2002_06
Patent number
US06407248B1

Reaction notes

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